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Drug-target interaction, molecular screening, ADMET, compound databases, pharmaceutical data
627 datasets
AU_AADC provides observed and predicted toxicity data from bioassays with two Antarctic marine microalgae species, Phaeocystis antarctica and Cryothecomonas armigera. The dataset includes results from exposures to mixtures of five metals at two ratios, with toxicity predicted using Independent Action and Concentration Addition models. The metadata record was last updated on April 30, 2018.
Antarctic soil nematodes from Clark Peninsula, Bailey Peninsula, and Robinsons Ridge were collected in the austral summer of 2013/14. The dataset likely contains counts of nematodes and eggs on agar plates, survival percentages in aqueous exposures, and measured copper concentrations from toxicity tests conducted at 15°C. Data was produced by AU_AADC and last updated in April 2016.
Three bioassays assess the toxicity of copper, cadmium, lead, zinc, and nickel to the Antarctic marine microalga Cryothecomonas armigera. Tests were conducted at 0°C over 23-24 days, measuring growth rates and cellular parameters like chlorophyll fluorescence and lipid content. The dataset, last updated in 2016, originates from the Australian Antarctic Data Centre.
Three gastropod species endemic to the subantarctic Macquarie Island were exposed to five concentrations of copper in controlled seawater tests. Experiments were conducted both on the island and at the Australian Antarctic Division in Tasmania between the 2013/14 austral summer and 2015. The description details precise collection habitats, laboratory acclimation periods, and strict water quality controls for the toxicity tests.
Six invertebrate species from Macquarie Island were exposed to copper, zinc, and cadmium in controlled 14-day laboratory tests. The study, conducted by AU_AADC and last updated in 2015, used a static non-renewal regime with five metal concentrations and a control, each with 3-5 replicates. Collection sites were verified as free of metal contamination via ICP-OES analysis of seawater.
February 2013 to April 2015 data from an in-situ mesocosm experiment on Macquarie Island assessing the toxicity of residual hydrocarbons on soil microbial communities. The dataset contains semi-processed and processed microfluidic qPCR results for 90 soil samples, assaying 14 functional genes, generated by the Australian Antarctic Data Centre. It includes gene copy numbers, treatment concentrations, and environmental parameters.
Bioassay results show the response of the Antarctic nemertean Antarctonemertes unilineata to contamination from Special Antarctic Blend diesel, Marine Gas Oil, and Intermediate Fuel Oil 180, chemically dispersed with Ardrox 6120, Slickgone LTSW, and Slickgone NS. Experiments were conducted at Casey station and the Antarctic Division's Marine Research Facility at 0°C, with sublethal and lethal endpoints assessed over 16 to 24 days. The dataset includes measurements of total hydrocarbon content from water samples taken before and after four-day water changes.
The dataset from the Australian Antarctic Division contains results from bioassays conducted between 19 July and 2 September 2014. It shows the response of Antarctic Polychaetes Ophryotrocha orensanzi to contamination from IFO 180 fuel and the dispersants Ardrox 6129, Slickgone LTSW, and Slickgone NS. Test solutions were prepared following specific methods and tested at controlled concentrations and temperatures.
Bioassay results from 2014 show the response of the Antarctic amphipod Paramoera walkeri to contamination from Special Antarctic Blend diesel, Marine Gas Oil, and Intermediate Fuel Oil, both alone and chemically dispersed. The data includes mortality curves and LC50 values derived from tests using Water Accommodated Fractions and Chemically Enhanced Water Accommodated Fractions prepared under controlled laboratory conditions. The dataset was contributed by the Australian Antarctic Data Centre (AU_AADC) and last updated on NASA's Earthdata platform in July 2014.
Antarctic bioassay data showing the response of the microgastropod Skenella palludinoides to Special Antarctic Blend diesel and Ardrox 6120 dispersant. The dataset contains results from Water Accommodated Fractions (WAF), Chemically Enhanced WAF (CEWAF), and dispersant-only treatments, with mortality curves and LC50 values calculated from experiments lasting up to 35 days. Data was collected by AU_AADC and last updated in May 2014.
Results from 11 bioassays conducted in 2014 assess the toxicity of five metals (copper, cadmium, lead, zinc, nickel) on two species of Antarctic marine microalgae. The dataset includes 7 tests with Phaeocystis antarctica and 4 tests with Cryothecomonas armigera, measuring growth rates, cell density, and other physiological parameters under controlled conditions. Data was aggregated by the Australian Antarctic Data Centre (AU_AADC) and published on NASA's Earthdata platform.
Bioassay results showing the response of larval Antarctic Sterechinus neumayeri sea urchins to contamination from IFO 180 fuel and Slickgone NS dispersant. The metadata record contains two spreadsheets detailing survival data and hydrocarbon analysis results from experiments conducted at 0°C. Data was produced by the Australian Antarctic Data Centre (AU_AADC) and last updated in February 2014.
Antarctic soil from the Thala Valley waste site at Casey Station was treated with silica or an orthophosphate-silica mix in a 2013 pilot study. The dataset contains Toxicity Characteristic Leaching Procedure (TCLP) results for leachable concentrations of copper, zinc, arsenic, and lead in treated and untreated soil samples. Data was analyzed by the Australian Antarctic Division using ICP-OES.
Two 14-day bioassays testing the toxicity of cadmium, copper, and zinc, both individually and in mixtures, to Antarctic marine copepods. The experiments were conducted during the 2012-2013 season at Davis Station, East Antarctica, with mortality counts and measured metal concentrations recorded. Data are provided in Excel workbooks containing point estimates like LC10 and LC50 values calculated at 4, 7, 10, and 14 days of exposure.
Integrated Total Hydrocarbon Content (THC) exposure concentrations in micrograms per liter, derived from water accommodated fractions of three marine fuels. Data was used to model sensitivity estimates for Antarctic invertebrates over exposure periods from 24 hours to 21 days. The dataset was produced by the Australian Antarctic Data Centre (AU_AADC) and last updated in June 2012.
AAS Project 3054 produced this dataset containing results of toxicity tests with early life stages of the Antarctic sea urchin Sterechinus neumayeri. Tests were conducted at Davis Station during the 2010/11 summer season to assess sensitivity to three fuel types: Special Antarctic Blend diesel, Marine Gas Oil diesel, and an intermediate grade Fuel Oil. The dataset consists of Excel spreadsheets with separate worksheets for test conditions and results.
A series of toxicity tests were conducted using the marine microgastropod Skenella paludionoides between 2006 and 2010. Tests determined the species' sensitivity to the common metal contaminants cadmium, copper, nickel, lead, and zinc. The data was collected by the Australian Antarctic Division, with biota sourced from Casey and Davis stations.
Two three-week toxicity tests were completed at Davis station in 2009/10 as part of STP project 3217. The dataset assesses the impact of sewage effluent on two key local invertebrate species, Paramoera walkeri and Skenella paludionoides, using standard bioassay protocols. Results provide a baseline for quantifying future changes to effluent discharge and determining safe dilution factors for the near-shore marine environment.
ASAC project 1163 collected soil toxicity data from the Casey Main Power House Special Antarctic Blend fuel spill site during the 2005-2006 austral summer. Soil was sampled nine times from 32 sites representing contamination levels from 0 to 25,000 mg kg-1 SAB. Assays measured carbohydrate utilization, nitrification, denitrification, and microbial biodiversity.
Eighteen experiments from 2005-2006 measured chlorophyll fluorescence decline in three Antarctic macroalgae species exposed to copper, zinc, and cadmium. Data consists of hourly 2D image files captured by a robotic PAM fluorometer, organized by experiment, species, metal, and duration. The dataset was collected at Casey Station by the Australian Antarctic Data Centre.