Shared Gene Signatures and Regulatory Networks Between Parkinson's and Ulcerative Colitis

320 shared signature genes identified between Parkinson's disease and ulcerative colitis. This supplementary dataset from a manuscript submitted to NPJ Parkinson's Disease includes differential expression lists, functional enrichment results, immune cell deconvolution profiles, and predicted regulatory networks. The data, authored by Xiaohui Sun and last updated in April 2026, is provided in Excel format under a CC-BY-4.0 license.

Use Cases

• Identifying shared pathogenic pathways based on the list of 320 common genes.
• Conducting functional enrichment analysis based on the provided GO and KEGG pathway results.
• Analyzing immune cell infiltration patterns based on the CIBERSORTx deconvolution profiles.
• Predicting therapeutic candidates based on the regulatory network of transcription factors, miRNAs, and drug interactions.

Strengths

• Includes a specific list of 320 shared signature genes with evidence from multiple databases.
• Provides comprehensive supplementary analysis outputs, including differential expression, functional enrichment, and immune cell profiling.
• Data is structured in five distinct Excel files, each corresponding to a major analysis step described in the manuscript.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

figshare, associated with a manuscript submitted to NPJ Parkinson's Disease.

Collection Method

Bioinformatics analysis of public gene expression datasets (e.g., GSE22491, GSE3365, GSE97760).

Freshness

Last updated 2026-04-29 09:19:08; freshness should be verified.