New Limonoid Compound Cytotoxicity Data from Chisocheton Macrophyllus Seeds

A 2026 study isolated and characterized a new limonoid compound, 11α-hydroxydysobinin, from Chisocheton macrophyllus seeds. The research includes structural data from HR-ESI-MS, UV, IR, NMR, and ECD analysis, along with cytotoxic activity test results against MCF-7 breast cancer cells. The dataset comprises a 2.1 MB DOCX file authored by Nurlelasari.

Use Cases

• Analyze the relationship between limonoid structure and cytotoxic activity using reported IC50 values against MCF-7 cells.
• Validate quantum chemical calculation methods (TD-DFT, DP4+ NMR) used for stereochemical configuration characterization.
• Compare the biological activity of the new compound 11α-hydroxydysobinin with the known limonoid compound also reported.

Strengths

• Includes specific IC50 values (112.5 and 51.7 µM) quantifying cytotoxic activity.
• Structural characterization employs multiple analytical techniques: HR-ESI-MS, UV, IR, NMR, and ECD.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• Dataset is a single 2.1 MB DOCX document, not a structured, machine-readable table.
• Sample size is limited to two tested compounds, restricting statistical analysis.
• No raw experimental data or columnar data is provided for direct computational analysis.

Provenance

Source

figshare

Collection Method

Chemical isolation and characterization from plant seeds, followed by biological assay.

Time Range

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Freshness

Last updated in March 2026.

Geography

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