Zhu and Abruzzo et al: Pneumococcal Capsule Effects on Infection

Raw data from a 2023 study investigates the role of capsular polysaccharide amount in pneumococcal-host interactions. The dataset includes numerical results from immunoblotting, flow cytometry, and an infant-mouse model of bacteremia. Data is stored in a GraphPad Prism file within a compressed archive.

Use Cases

• Analyzing the correlation between polysaccharide production and bacterial virulence based on immunoblotting data
• Comparing in vivo infection outcomes in an infant-mouse model across different bacterial strains
• Re-plotting or re-analyzing experimental results using the provided GraphPad Prism file

Strengths

• Data is directly linked to a peer-reviewed publication in PLOS Pathogens, providing context and validation
• Includes data from multiple experimental methods: immunoblotting, flow cytometry, and an in vivo mouse model
• Available under a permissive CC-BY-4.0 license for reuse

Limitations

• Column names and a precise row count are not provided, limiting immediate understanding of the data structure
• The dataset consists of raw files in a proprietary GraphPad Prism format, requiring specific software for full access
• Metadata is sparse, with no information on the organization or specific experimental parameters

Provenance

Source

Hannes Eichner, associated with the PLOS Pathogens article 'Effects of Capsular Polysaccharide amount on Pneumococcal-Host interactions'

Collection Method

Experimental data generated from laboratory immunoblots, flow cytometry, and an infant-mouse infection model

Time Range

2023

Freshness

Last updated on 2026-03-20