Bone Marrow-Targeting Nanosystem for Hematologic Malignancies Therapy

This dataset contains 668.1 KB of DOCX and XLS files describing a bone marrow-targeting nanosystem (CSF1R-H) for treating hematologic malignancies. The nanosystem uses hematopoietic stem cell-derived nanovesicles with gripper ligands and encapsulated colony-stimulating factor to target tumor cells and activate NK cells. Therapeutic efficacy was validated in mouse models of AML and MM, showing improved bone marrow microenvironment and relapse prevention.

Use Cases

• Evaluate bone marrow-targeting efficiency of nanosystems
• Analyze NK cell activation against tumor cells in vitro
• Test therapeutic outcomes in AML and MM animal models

Strengths

• Validated in two mouse models (AML and MM)
• Demonstrates bone marrow microenvironment improvement
• Includes safety and specificity assessments

Limitations

• Row and column counts unknown
• No sample data available for direct inspection
• Documentation may require preprocessing from raw files

Provenance

Source

figshare

Collection Method

Uploaded by author Yan qin Zhang

Time Range

Last updated 2026-05-12 10:14:51