BsPep-IMDQ Conjugate Structure for LAG-3 and PD-L1 Immune Checkpoint Targeting

Loaded with the PDB structure file for BsPep-IMDQ, a bispecific peptide-drug conjugate designed to target LAG-3 and PD-L1 immune checkpoints and deliver a TLR7/8 agonist. It was authored by Yuzhen Qian and published on figshare in March 2026 under a CC BY-NC 4.0 license. The file size is 172.4 KB.

Use Cases

• Analyze the 3D structure of the BsPep-IMDQ conjugate to understand its binding interfaces for LAG-3 and PD-L1.
• Use the PDB file for molecular docking simulations to study interactions with immune checkpoint proteins.
• Investigate the MMP-cleavable linker region within the structure to model drug release mechanisms in the tumor microenvironment.

Strengths

• The PDB file provides a precise 3D structural model of the novel BsPep-IMDQ conjugate.
• The dataset is associated with peer-reviewed research demonstrating antitumor efficacy in MC38 and B16 tumor models.
• The file is small (172.4 KB), ensuring fast download and easy handling.

Limitations

• The dataset is a single, static 3D structure file with no associated experimental data or time-series information.
• Its scope is limited to the molecular structure, lacking tabular data on biological assays, row counts, or columnar features.
• The file format (PDB) requires specialized bioinformatics or molecular visualization software for analysis.

Provenance

Source

figshare

Collection Method

Presumably derived from computational modeling or structural determination as part of the published research.

Freshness

Last updated March 2026.