Organelle-Directed Photocytotoxic Ruthenium(II) Probe Data

Creina Slator's dataset describes Ru(II) polypyridyl complexes coupled to a triphenylphosphonium vector via click chemistry for cellular imaging. Evidence of cellular localization, predominantly in mitochondria, was derived from live-cell confocal fluorescence microscopy. The dataset was last updated on May 12, 2026.

Use Cases

• Training models to predict cellular localization of metal complexes based on ligand design.
• Analyzing the relationship between probe structure (e.g., TPP-phen vs. TPP-dppz) and environmental stability from spectroscopic data.
• Benchmarking DNA intercalation efficiency for nucleic acid probe candidates.

Strengths

• Dataset includes specific chemical modifications described, such as azide-functionalized ligands and alkyne-modified TPP moieties.
• Description references concrete experimental evidence from live-cell confocal fluorescence microscopy.

Limitations

• Dataset size is only 1.2 KB, indicating extremely limited scope and likely minimal data points.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Creina Slator via figshare

Collection Method

Likely contains experimental results from spectroscopic solution studies and luminescence imaging.

Freshness

Last updated 2026-05-12 18:26:12; freshness should be verified.