C. elegans Insulin Signaling and Lifespan Modulation via ZFP-1 and RDE-4

Research data from Columbia University explores the role of conserved PHD finger protein ZFP-1 and RNAi factor RDE-4 in modulating insulin signaling and lifespan in Caenorhabditis elegans. The study identifies their negative regulation of PDK-1 transcription and links it to oxidative stress resistance and longevity. Findings suggest epigenetic and RNAi mechanisms significantly impact signaling pathway outcomes.

Use Cases

• Modeling lifespan and stress response based on genetic perturbations of zfp-1 and rde-4 mentioned in the description
• Analyzing gene expression relationships between PDK-1, DAF-16, and SKN-1 transcription factors described in the study
• Investigating epigenetic regulation of insulin/PI3 signaling pathways based on the described functions of ZFP-1

Strengths

• Data originates from a specific research study published on an academic platform, providing a clear scientific context.
• The description details concrete biological relationships, such as the modulation of pdk-1 transcription by ZFP-1 and RDE-4.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Likely contains experimental results from genetic and molecular biology studies on C. elegans strains.