Adverse Outcome Pathways: Gene and Biological System Annotations for Human Health

Laura Aliisa Saarimäki and colleagues from Tampere University published a molecular annotation of Adverse Outcome Pathways (AOPs) relevant to human health in 2023. The dataset embeds the AOP framework into molecular data interpretation to support the development of new approach methodologies for chemical safety assessment. It was released on Zenodo alongside a publication in Scientific Data.

Use Cases

• Interpret molecular data within the Adverse Outcome Pathway framework based on the described annotation.
• Guide the development of new approach methodologies (NAMs) for chemical safety based on the multi-scale biological models.
• Support biomedical research into biological mechanisms connecting molecular events to adverse health outcomes.

Strengths

• Published in a peer-reviewed journal (Scientific Data, 2023).
• Explicitly linked to a specific publication with a DOI (10.1038/s41597-023-02321-w).
• Authored by researchers from an academic institution (Tampere University).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Tampere University

Collection Method

Curated molecular annotation based on published Adverse Outcome Pathways.