ADAMTS7 Polymorphism Association with Stroke Incidence and Prognosis

A study of 1,027 patients and 1,043 controls found the rs1045130 A allele significantly increases susceptibility to large artery atherosclerotic stroke, worsens short-term outcomes, and raises one-month recurrence risk. Linfa Chen published this research on figshare in 2026. The work links a genetic mutation disrupting miR-654-5p regulation to elevated ADAMTS7 expression and foamed vascular smooth muscle cell proliferation.

Use Cases

• Assessing genetic risk factors for stroke based on the rs1045130 SNP association
• Investigating molecular pathways in atherosclerosis based on the ADAMTS7-miR-654-5p axis described
• Studying prognosis and recurrence in stroke patients based on genotype and short-term outcome data
• Analyzing gene expression in vulnerable plaques based on findings in endothelial cells, smooth muscle cells, and macrophage-derived foam cells

Strengths

• Includes data from two independent case-control cohorts totaling 2,070 individuals
• Links genotype (rs1045130) to concrete clinical outcomes: incidence, short-term prognosis, and one-month recurrence
• Provides mechanistic explanation linking polymorphism to molecular pathway disruption and cell behavior

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect geographic bias inherent to the southern Chinese population studied

Provenance

Source

figshare

Collection Method

Genotyping analyses and quantification of ADAMTS7 expression and downstream molecular effects conducted on patient cohorts.

Freshness

Last updated 2026-05-25 23:20:03; freshness should be verified

Geography

Southern Chinese population