SHP2 Phosphorylation Site Data for Oncoprotein Activation Analysis

21.4 MB of research data from figshare, uploaded by Prashath Karunaraj on April 10, 2026. The dataset likely contains experimental results related to phosphorylation of SHP2 at tyrosine 62, a mechanism of resistance to allosteric inhibitors. It includes files in XLSX, ZIP, PDB, and MTZ formats.

Use Cases

• Identify phosphorylation-driven drug resistance mechanisms based on the described pY62 biomarker.
• Analyze SHP2 conformational states based on the mention of open, active SHP2 conformation.
• Correlate phosphorylation sites with oncogenic mutations based on the described phenocopying of PTPN11 mutations.
• Evaluate potential therapeutic biomarkers based on the nomination of pY62 as a biomarker for therapeutic response.

Strengths

• Dataset size is 21.4 MB, indicating a manageable download.
• Includes multiple file formats (XLSX, ZIP, PDB, MTZ) likely containing complementary data types.
• License is CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Freshness

Last updated 2026-04-10 07:03:51; freshness should be verified.