Multi-Center MRI Data for Systemic Lupus Erythematosus with Clinical Assessments

631 participants, including 346 patients with systemic lupus erythematosus and 285 healthy controls, contributed preprocessed resting-state fMRI and diffusion tensor imaging data collected across four clinical centers in China. The dataset provides regional-level imaging data, harmonized for cross-center batch effects, and includes clinical assessments for a subset. Peng Ding authored this resource, last updated on April 28, 2026.

Use Cases

• Analyze functional connectivity patterns based on regional mean BOLD time series extracted using the AAL atlas.
• Model structural brain connectivity based on matrices derived from fractional anisotropy and fiber number.
• Investigate structure-function coupling in SLE based on multimodal data from the same subjects available at three centers.
• Correlate neuroimaging features with disease activity based on included clinical scores like SLEDAI.
• Study cross-center data harmonization effects based on the described ComBat processing pipeline.

Strengths

• Includes data from 631 participants, a substantial sample size for a clinical neuroimaging study.
• Multimodal data (rs-fMRI and DTI) are available from the same subjects at three of the four centers, enabling integrated analyses.
• Systematic quality control was applied, including head motion screening and cross-center harmonization, with no significant differences reported across 116 brain regions post-harmonization.
• Clinical and neuropsychological assessments, such as SLEDAI scores, are included for a subset of participants.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Clinical assessments are only available for a subset of participants, not the full cohort.
• The data's geographic coverage is limited to four centers in China, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Multi-center collection of preprocessed MRI data using standardized pipelines.

Time Range

null

Freshness

Last updated 2026-04-28 02:56:03; freshness should be verified.

Geography

Four clinical centers in China.