Vadadustat Prodrug 11: Neuroprotection Data in Mouse Ischemic Stroke Model

A preclinical dataset from figshare, authored by Ke Li and last updated on 2026-05-02, describes a near-infrared photoactivatable prodrug for neuroprotection. The data likely contains results from in vitro HT22 cell assays under oxygen-glucose deprivation and in vivo mouse cerebral ischemia-reperfusion models. The findings highlight a strategy for spatiotemporally controlled drug release in the brain.

Use Cases

• Evaluating neuroprotective efficacy based on infarct volume and brain edema measurements from the mouse model.
• Assessing in vitro cell viability based on oxygen-glucose deprivation/reoxygenation (OGD/R) experiments in HT22 cells.
• Analyzing the impact of spatiotemporally controlled drug release based on near-infrared irradiation protocols.
• Studying blood-brain barrier penetration strategies based on the prodrug design masking an acidic pharmacophore.

Strengths

• Dataset is openly available under a CC-BY-NC-4.0 license.
• The description provides specific experimental details, including the use of HT22 cells and a mouse I/R model.
• The data is associated with a specific, recent update timestamp (2026-05-02).

Limitations

• The dataset is extremely small at 612.0 B, indicating very limited scope.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data may reflect the specific experimental bias inherent to the single preclinical study described.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from in vitro cell assays and in vivo mouse model studies.

Freshness

Last updated 2026-05-02 13:33:28; freshness should be verified.