Mouse Model Data for Ozone-Induced Lung Inflammation and Fibrosis

Gregory J. Smith published experimental data comparing ozone responses between CC002/Unc and C57BL/6J mouse strains. The dataset includes results from acute and repeated ozone exposure tests, along with quantitative trait loci mapping for airway eosinophilia. It was last updated on May 13, 2026.

Use Cases

• Benchmarking ozone sensitivity in rodent models based on strain comparison data.
• Identifying genetic loci for ozone-induced lung disease based on quantitative trait loci mapping.
• Studying the relationship between thermoregulatory response and pollutant sensitivity based on described physiological measurements.
• Investigating mechanisms of eosinophilic inflammation and centriacinar fibrosis from repeated ozone exposure.

Strengths

• Data compares two distinct mouse strains (CC002/Unc and C57BL/6J) across multiple exposure protocols.
• Includes genetic mapping results, identifying a large-effect QTL on chromosome 11 accounting for 18% of phenotypic variation.
• The dataset is 1.8 MB in size and available in XLSX format for direct analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific experimental model and figshare platform.

Provenance

Source

figshare

Collection Method

Experimental data from controlled ozone exposure studies on mice.

Freshness

Last updated 2026-05-13 17:36:20; freshness should be verified.