AZD9574: Preclinical PET Imaging Data for PARP1 in Cancer Models

A novel 18F-labeled PET ligand, [18F]AZD9574, was evaluated for imaging Poly(ADP-ribose) polymerase-1 (PARP-1). The dataset likely contains results from testing in breast, glioblastoma, prostate, and pancreatic cancer cell lines and 22Rv1 xenograft mouse models, authored by Steven Liang and harvested by ODUM. The record was last updated on 2026-04-27.

Use Cases

• Validate PARP1-specific tracer binding based on correlation with PARP-1 expression mentioned in the description
• Assess tracer specificity for PARP1 based on dose-dependent blocking by clinical PARP inhibitors
• Evaluate tumor accumulation and biodistribution of novel PET ligands in preclinical xenograft models
• Compare PARP1 expression levels across a panel of breast, glioblastoma, prostate, and pancreatic cancer cell lines

Strengths

• Data is derived from testing across a panel of four cancer types: breast, glioblastoma, prostate, and pancreatic
• Findings include confirmation of binding specificity through dose-dependent blocking by clinically relevant PARP inhibitors
• Tracer performance was validated in 22Rv1 xenograft mouse models with ex vivo biodistribution

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

Steven Liang, ODUM Harvested Dataverse

Collection Method

Likely contains experimental results from in vitro cell line testing and in vivo mouse model studies.

Time Range

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Freshness

Last updated 2026-04-27 03:12:13; freshness should be verified

Geography

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