A Novel <i>Przondovirus</i> Bacteriophage Combats <i>Klebsiella pneumoniae</i> through Evo

A 1.7 MB dataset from figshare, last updated on 2026-04-13, authored by Hanyu Fu. It contains experimental data on a novel Przondovirus bacteriophage, P1524, which combats carbapenem-resistant hypervirulent Klebsiella pneumoniae. The data likely includes results on phage-host co-evolution, virulence factors, and metabolic pathway analysis.

Use Cases

• Analyzing phage-host co-evolution dynamics based on the described wcaJ mutation and capsule loss.
• Modeling the impact of phage effectors (Orf4, Orf15, Orf23) on bacterial virulence and survival in Galleria mellonella models.
• Investigating metabolic reprogramming in Klebsiella pneumoniae based on the described downregulation of enzymes (AldB_1, AlsS, BudC) in the 2,3-butanediol fermentation pathway.
• Studying the trade-off between phage resistance and virulence reduction in high-risk bacterial clones (ST11, ST14, ST65).

Strengths

• Data is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• File size is 1.7 MB, making it quick to download and inspect.
• The description provides a detailed molecular mechanism for phage action and host resistance.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (1.7 MB), which may limit the scope of analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from phage characterization and host interaction studies.

Time Range

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Freshness

Last updated 2026-04-13 14:39:14; freshness should be verified.

Geography

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