CN-2 MAGL-Activatable Fluorogenic Probe Data for Inhibitor Discovery

Lele Liu developed a high-performance fluorogenic probe, CN-2, for screening monoacylglycerol lipase (MAGL) inhibitors. The dataset likely contains results from a high-throughput screening platform that identified three potent competitive inhibitors (A5, A11, F10). The data was last updated on 2026-05-30 and is shared under a CC-BY-NC-4.0 license.

Use Cases

• Screen for potent MAGL inhibitors based on signal enhancement and kinetic behavior data.
• Validate anti-inflammatory effects of compounds based on attenuation of LPS-induced responses.
• Assess hepatoprotective potential of agents based on reduction of ALT, AST, LDH, and ROS markers.
• Discover novel therapeutic agents for drug-induced liver injury based on data from human liver organoids.

Strengths

• The probe CN-2 was developed through three rounds of structural optimization, suggesting a methodical design process.
• The screening platform identified three specific, potent competitive MAGL inhibitors (A5, A11, F10).
• Data includes validation in both cell-based (macrophages, hepatocytes) and organoid (human liver) models.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale at 336.7 KB, indicating limited scope.

Provenance

Source

Lele Liu via figshare

Collection Method

Likely contains experimental data from the development and application of the CN-2 fluorogenic probe.

Freshness

Last updated 2026-05-30 14:04:52; freshness should be verified.