Review on Impurity Profiling and Bio-Analytical Methods for Antifungal Drugs

A 873.5 KB review document authored by Trupesh Pethani, last updated on June 1, 2026. It discusses impurity profiling, forced degradation studies, and bioanalytical method development for antifungal agents, covering major drug classes like azoles and polyenes. The review consolidates analytical strategies aligned with ICH and pharmacopeial standards.

Use Cases

• Reviewing impurity types and control strategies based on the discussion of organic, inorganic, and residual solvent impurities.
• Planning forced degradation studies based on the evaluation of stress conditions for drugs like flucytosine and terbinafine.
• Selecting analytical techniques for impurity detection based on the highlighted use of HPLC, LC–MS/MS, and GC–MS.
• Designing bioanalytical method validation for pharmacokinetic studies based on the outlined advances in LC–MS/MS and UPLC–MS/MS.

Strengths

• The review consolidates information on impurity profiling, degradation studies, and bioanalytical methods into a single integrated framework, which the description states is a novel approach.
• It covers multiple major antifungal drug classes, including azoles, polyenes, allylamines, and pyrimidine analogues.
• The document is licensed under CC-BY-4.0, allowing for open sharing and adaptation.

Limitations

• The dataset is a single 873.5 KB DOC file, indicating a limited scope of a review article rather than primary research data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for data-driven tasks.

Provenance

Source

figshare

Collection Method

Authored review article.

Freshness

Last updated 2026-06-01 18:31:39; freshness should be verified.