Targeted and Untargeted Sugar Profiles from Human Urine and Serum

A combined targeted and untargeted sugaromics method quantified various sugars in 40 urine and 36 serum samples, while also identifying untargeted compounds in 35 urine and 22 serum samples. The dataset, authored by Elisa E. Streitenberger and last updated in March 2026, presents a GC×GC‑MS approach validated using FDA and ICH guidelines. Absolute concentrations for seven sugars in urine and 14 in serum were reported for healthy adults for the first time.

Use Cases

• Validate analytical methods for sugar quantification based on the described fit-for-purpose validation parameters.
• Identify novel sugar biomarkers for health and nutrition studies based on the untargeted profiling approach.
• Compare sugar concentration ranges in human biofluids based on the reported absolute concentrations for 7 urine and 14 serum sugars.
• Investigate the impact of diet or health on sugar metabolism based on the described link between sugar profiles and lifestyle factors.

Strengths

• Validation follows FDA and ICH guidelines, with the majority of sugars demonstrating satisfactory validity parameters.
• Reports absolute concentrations for 7 sugars in urine and 14 in serum for healthy adults for the first time.
• Method combines targeted quantification and untargeted identification, covering a broader sugar profile.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Sample size is limited to 40 urine and 36 serum samples for targeted analysis.

Provenance

Source

figshare

Collection Method

Two-dimensional gas chromatography coupled with mass spectrometry (GC×GC‑MS) applied to human biofluid samples.

Freshness

Last updated 2026-03-18 23:33:28; freshness should be verified.