MBX-4132: Transcriptomic Data on Trans-Translation Inhibition in Mycobacteria

Akanksha Varshney published transcriptomic data on figshare in April 2026. The dataset likely contains gene expression measurements from Mycobacterium tuberculosis and other pathogenic mycobacteria exposed to the acylaminooxadiazole inhibitor MBX-4132. The findings demonstrate the compound's bactericidal activity and its interaction with iron and zinc homeostasis.

Use Cases

• Analyzing gene expression dysregulation in metal homeostasis pathways based on transcriptomic data
• Investigating the link between zinc sensing and efflux genes and trans-translation inhibition
• Evaluating the bactericidal potency of MBX-4132 against multiple mycobacterial species
• Studying the antagonistic effect of iron and potentiating effect of zinc on acylaminooxadiazole activity

Strengths

• Data is associated with a published scientific investigation into a novel antibiotic target
• The dataset is available under a CC-BY-NC-4.0 license, allowing for non-commercial reuse
• File format is XLSX, which is widely accessible

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is 603.5 KB, indicating a limited scope of data

Provenance

Source

Akanksha Varshney

Freshness

Last updated 2026-04-09 05:43:34