MBX-4132 Antibiotic Potency Data Against Mycobacteria

Experimental data on the acylaminooxadiazole MBX-4132, a trans-translation inhibitor, demonstrates bactericidal activity against Mycobacterium tuberculosis and nontuberculous mycobacteria. The dataset includes transcriptomic results showing dysregulation of metal homeostasis pathways and the potentiating effect of zinc on the compound. Author Akanksha Varshney published the 8.5 MB Excel file on figshare in April 2026.

Use Cases

• Modeling drug potency based on transcriptomic dysregulation of metal homeostasis pathways
• Analyzing the antagonistic effect of iron on acylaminooxadiazole activity
• Investigating zinc-sensing gene expression changes when trans-translation is inhibited
• Evaluating bactericidal efficacy against Mycobacterium tuberculosis in macrophages

Strengths

• Data demonstrates bactericidal activity against multiple pathogenic mycobacterial species
• Includes transcriptomic data revealing dysregulation of metal homeostasis pathways
• File size is 8.5 MB, indicating a substantial amount of experimental data

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Freshness

Last updated 2026-04-09 05:43:34