AA5208/OCTANE: HIV Treatment Efficacy in African Women with Low CD4 Counts

500 antiretroviral-naïve HIV-infected women with CD4 counts below 200 cells/mm³ were enrolled in a clinical trial across seven African countries. The AA5208/OCTANE trial, published in PLOS in 2012, compared the efficacy and safety of two initial antiretroviral regimens. The dataset was provided by the ACTG Statistical and Data Analysis Center.

Use Cases

• Compare virologic efficacy between NNRTI and PI-based regimens based on the trial's primary objective.
• Analyze rates of treatment discontinuation and adverse events based on the conclusions mentioned in the description.
• Study the emergence of new drug resistance patterns based on the findings comparing the two treatment arms.
• Model treatment outcomes for women with low CD4 counts based on the specific patient population described.

Strengths

• Data originates from a multi-country clinical trial with 500 participants, providing a defined study population.
• The dataset includes trial results published in a peer-reviewed journal (PLOS 2012).
• The description provides clear primary and secondary outcomes (virologic efficacy, discontinuation, resistance).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific modeling tasks.
• The dataset size is 13.9 MB, suggesting a relatively small scale for modern ML applications.

Provenance

Source

ACTG Statistical and Data Analysis Center

Collection Method

Clinical trial (AA5208/OCTANE)

Time Range

Trial period leading to 2012 publication

Freshness

Last updated 2026 03 18 16:38:47; freshness should be verified.

Geography

Seven African countries: Botswana, Kenya, Malawi, South Africa, Uganda, Zambia, Zimbabwe