Long-Term Follow-up of Older HIV-Infected Adults in ACTG Trials

Aggregating 1,035 evaluable participants from the A5322 (HAILO) long-term observational study. Participants were aged 40 or older, ART-naïve at entry into the parent ALLRT study, and were followed for approximately 7 years (336 weeks) to evaluate clinical, virologic, and immunologic outcomes associated with aging and long-term ART.

Use Cases

• Analyze associations between aging and long-term clinical outcomes in HIV-infected adults over a 336-week follow-up period.
• Evaluate virologic and immunologic outcomes in a cohort of 1,035 participants who were ART-naïve at parent protocol enrollment.
• Study potential long-term effects of potent antiretroviral therapy in a population aged 40 years and older.
• Investigate outcomes with a cohort planned to include approximately 22% female participants, corresponding to the eligible population.

Strengths

• 1,035 evaluable participants provide a substantial cohort for longitudinal analysis.
• Longitudinal design with a planned 336-week (approximately 7-year) follow-up period for long-term outcome assessment.
• Study population is defined with specific inclusion criteria: age 40+, ART-naïve at parent protocol entry, and actively followed in the ALLRT study.

Limitations

• The dataset is closed to accrual as of July 31, 2014, limiting the inclusion of newer treatment regimens or patient experiences.
• Specific data columns, sample data, and file formats are unknown, which may complicate initial data exploration and analysis.
• The cohort, while substantial, may have limited generalizability to younger HIV populations or those with different treatment histories.

Provenance

Source

ACTG Statistical and Data Analysis Center, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections.

Collection Method

Long-term observational study (A5322 protocol) following participants from the Adult AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT/A5001) study.

Time Range

Study follow-up duration was 336 weeks (~7 years); accrual closed on July 31, 2014.

Freshness

The metadata was last updated on 2026-02-09, but the study data collection closed in 2014.