A5324: A Randomized, Double-Blinded, Placebo-Controlled Trial Comparing Antiretroviral Int

A5324 is a 96-week, randomized, double-blind, placebo-controlled clinical trial involving 191 participants with HIV and neurocognitive impairment. The trial, conducted by the ACTG Statistical and Data Analysis Center, compared three antiretroviral intensification regimens and measured outcomes including cognitive function, depressive symptoms, and body mass index. The dataset includes results from participant screening and the 96-week study period.

Use Cases

• Analyzing the efficacy of different antiretroviral intensification regimens on cognitive function based on total z score results.
• Studying changes in depressive symptoms and daily functioning over time in a controlled HIV population.
• Investigating the relationship between body mass index changes and specific drug regimens over a 96-week period.
• Evaluating adverse event rates and discontinuation reasons across different treatment arms in a clinical trial setting.

Strengths

• Data originates from the largest randomized, placebo-controlled trial of ART intensification for neurocognitive impairment in people with HIV.
• Includes detailed demographic information for 191 participants, such as mean age (52 years), mean CD4+ count (681 cells/µL), and breakdown by sex (71% male), race (51% Black), and ethnicity (22% Hispanic).
• Longitudinal data covering a 96-week study period with multiple measured outcomes.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.
• The dataset's 19.3 MB size suggests it may be a documentation or summary dataset rather than the full raw clinical trial data.

Provenance

Source

ACTG Statistical and Data Analysis Center

Collection Method

Randomized, double-blind, placebo-controlled clinical trial.

Time Range

Covers a 96-week trial period.

Freshness

Last updated 2026-03-18 16:16:37; freshness should be verified.

Geography

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