Iron Absorption from Ferritin in Women and Rat Intestinal Segments

A clinical and ex vivo study investigates the bioavailability and absorption mechanism of iron from ferritin compared to other iron sources. The research involved healthy women receiving radiolabeled ferritin iron and rat intestinal segments perfused with ferritin or chelated iron. The dataset likely contains results from these experiments, such as iron absorption rates and transport comparisons.

Use Cases

• Compare iron absorption mechanisms based on results from human and rat model experiments described.
• Model the bioavailability of ferritin iron as a slow-release source based on the described RBC iron incorporation findings.
• Investigate the inhibitory effects of non-ferritin iron competitors on absorption based on the described dose-response results.
• Study the role of endogenous enterocyte ferritin in iron storage based on the described steady-state measurements.

Strengths

• Includes data from a human clinical study with healthy women, as described.
• Provides comparative data from ex vivo experiments using rat intestinal segments, as described.
• Uses radiolabeling (RBC 59 Fe) for precise iron absorption tracking, as mentioned in the description.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of California, Berkeley, author Elizabeth C. Theil, via paperswithcode.

Collection Method

Data likely gathered from controlled human clinical trials and ex vivo rat intestinal perfusion experiments, as described.