Acoustophoretic Platelet Purification: Feasibility and Impact on Activation and Function

A research dataset from paperswithcode evaluates an acoustic-based method for isolating human platelets from whole blood. The study compares platelet purity, activation status, and functionality between acoustophoresis and a reference soft-spin centrifugation protocol. Results indicate acoustophoresis eliminates over 80% of red blood cells and leukocytes, achieving a mean platelet purity of 92.8 ± 12.8% with minimal activation.

Use Cases

• Compare platelet isolation methods based on purity and activation metrics described in the study.
• Model platelet reactivity based on flow cytometry measurements of P-selectin and integrin αIIbβ3 expression.
• Assess thrombus incorporation potential of processed platelets using data from the ferric chloride-induced thrombosis model.

Strengths

• Provides specific quantitative results, including over 80% elimination of contaminating cells and a mean platelet purity of 92.8 ± 12.8%.
• Compares multiple evaluation metrics: purity, activation status, reactivity to collagen/thrombin, and in-vivo thrombus incorporation.

Limitations

• Row count and specific column-level data are unknown, limiting suitability assessment for direct analysis.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Pierre Bohec via paperswithcode

Collection Method

Experimental data from a study comparing acoustophoresis and centrifugation for platelet isolation.