Cu(II) Complex Crystallographic Data for Cancer Therapy Research

Crystallographic Information Files (CIF) for seven pyridine-hydrazone-derived Cu(II) complexes, including the potent Cu2 compound. The data, authored by Hai-Qun Zhang and last updated in April 2026, supports research into metal-based agents that disrupt organelle communication. The 506.8 KB dataset is shared under a CC-BY-NC-4.0 license on figshare.

Use Cases

• Analyzing molecular structures of Cu(II) complexes based on the provided CIF files.
• Studying the relationship between complex structure and cytotoxicity based on the described selective potency of Cu2.
• Investigating mechanisms of redox homeostasis disruption based on the described glutathione depletion and hydroxyl radical generation.
• Modeling organelle crosstalk in cancer therapy based on the described concurrent ER stress and mitochondrial dysfunction.

Strengths

• Includes CIF files for seven distinct Cu(II) complexes (Cu1–Cu7).
• Dataset is focused on a specific molecular strategy with a described mechanism of action.
• Has a clear license (CC-BY-NC-4.0) and author attribution.

Limitations

• The dataset is very small at 506.8 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Freshness

Last updated 2026-04-21 05:29:58; freshness should be verified.