Cu(II) Complex Activation Data for Synergistic Cell Death in Cervical Cancer

A 561.5 KB dataset from figshare details the molecular mechanism of a pyridine-hydrazone-derived Cu(II) complex, Cu2, which induces cell death. The work by Hai-Qun Zhang, last updated in April 2026, demonstrates Cu2's antitumor and antimetastatic efficacy in a cervical cancer model with minimal systemic toxicity. The data, shared under a CC-BY-NC-4.0 license, is provided in CIF format.

Use Cases

• Analyzing the relationship between glutathione depletion and hydroxyl radical generation based on the described redox cycle.
• Modeling the self-amplifying ROS–Ca2+ feedback loop that drives synergistic ferroptosis and apoptosis.
• Investigating the functional crosstalk between endoplasmic reticulum stress and mitochondrial dysfunction as a cancer therapy target.
• Evaluating the selective cytotoxicity and biocompatibility of copper-based complexes like Cu2 against cancer cells.

Strengths

• The dataset is associated with a specific, potent Cu(II) complex (Cu2) with demonstrated antitumor efficacy.
• The description provides a detailed mechanistic pathway involving redox homeostasis, ER stress, and mitochondrial dysfunction.
• Data is shared under a clear, open license (CC-BY-NC-4.0).

Limitations

• The dataset is very small at 561.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from biochemical and in vivo studies.

Freshness

Last updated 2026-04-21 05:29:57; freshness should be verified.