HNF1B in Bladder Cancer: Methylation, Expression, and Functional Analysis

Supplementary figures and data from a study on HNF1B in bladder cancer (BLCA). The dataset includes Kaplan-Meier survival analysis, IHC images, cell line functional assays, and correlation analyses with methylation and CNV from the TCGA-BLCA cohort. It was authored by Cong Luo and last updated on 2026-05-26.

Use Cases

• Validate HNF1B as a prognostic biomarker based on Kaplan-Meier survival analysis.
• Study the correlation between DNA methylation and gene expression using promoter methylation data.
• Analyze transcriptomic alterations from RNA sequencing of HNF1B-knockdown and overexpressing cells.
• Investigate genetic alterations like SNPs and CNV associated with HNF1B in bladder cancer.
• Assess cell proliferation, migration, and invasion from functional assay results.

Strengths

• Includes data from multiple sources such as the Xiangya cohort, TCGA-BLCA cohort, and the Human Protein Atlas (HPA).
• Contains results from multiple experimental methods including qRT-PCR, Western blot, CCK-8, colony formation, wound healing, and Transwell assays.
• License is CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The 20.2 MB file size suggests a relatively small dataset, potentially limiting the scope of independent analysis.
• Description metadata is limited; actual data quality and structure require verification upon download.

Provenance

Source

figshare, associated with a research publication.

Collection Method

Likely contains aggregated experimental and public genomic data from cell line studies and the TCGA-BLCA cohort.

Freshness

Last updated 2026-05-26 04:08:38; freshness should be verified.