GLYATL1: ATAC-Seq Data on Chromatin Accessibility in Luminal Breast Cancer Cells

3.8 MB of supplementary data from a study on GLYATL1 in luminal breast cancer. The dataset contains chromosomal coordinates and statistical metrics for differentially accessible chromatin regions identified via ATAC-sequencing in MCF7 parental and long-term estrogen deprived (LTED) cells. It was authored by Janina Müller and last updated on April 30, 2026.

Use Cases

• Identify differentially accessible chromatin regions based on log2 fold change and p-value columns.
• Analyze epigenetic changes associated with endocrine resistance based on comparisons between LTED and parental cell lines.
• Integrate chromatin accessibility data with other genomic datasets using the provided hg38 chromosomal coordinates.

Strengths

• Data includes FDR-adjusted p-values, a standard correction for multiple hypothesis testing.
• Raw sequencing data is available via a public repository (GHGA) under accession number GHGAD24495022399035.
• The dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, from the study 'GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer'.

Collection Method

ATAC-sequencing libraries were generated using a tagmentation protocol. Reads were aligned to hg38 and peaks were called with MACS2.

Freshness

Last updated 2026-04-30 04:13:32; freshness should be verified.