GLYATL1 Study: Transcription Factor Activity Scores in Luminal Breast Cancer Cells

Supplementary Table 4 from a 2026 study by Janina Müller, published on figshare. The dataset contains DoRothEA scores and p-values predicting transcription factor activities from RNA-sequencing data. It compares MCF7 parental cells, long-term estrogen deprived (LTED) cells, and GLYATL1 knockout clones.

Use Cases

• Identify key transcription factors driving endocrine resistance based on DoRothEA activity scores.
• Compare transcription factor activity changes between parental and estrogen-deprived breast cancer cell lines.
• Validate the role of GLYATL1 in epigenetic regulation by analyzing activity in knockout clones.

Strengths

• Data is derived from RNA-sequencing analysis using established R packages (limma, decoupleR).
• Includes statistical confidence measures (p-values) for each transcription factor activity prediction.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small (8.3 KB), indicating limited scope.
• Row count and specific column definitions are unknown, requiring manual inspection after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Differential gene expression analysis of RNA-sequencing data, with transcription factor activity estimated using the decoupleR package and the DoRothEA database.

Freshness

Last updated 2026-04-30 04:13:32; freshness should be verified.