GLYATL1 Proteomic Analysis in Luminal Breast Cancer Cell Lines

Supplementary proteomic data from a study on GLYATL1 in luminal breast cancer. The dataset contains log2 transformed protein intensities and fold-changes from DIA mass spectrometry analysis of MCF7 parental and long-term estrogen deprived (LTED) cells, including LTED GLYATL1 knockout clones. Janina Müller authored this dataset, which was last updated on 2026-04-30.

Use Cases

• Identify differentially expressed proteins associated with endocrine resistance based on log2 fold-change comparisons.
• Analyze proteomic changes in GLYATL1 knockout cell lines based on quantified protein intensities.
• Validate mass spectrometry findings from the associated ProteomeXchange repository (PXD067936) using the provided supplementary data.

Strengths

• Data is derived from DIA mass spectrometry, a quantitative proteomics method.
• Statistical analysis includes Benjamini-Hochberg adjusted p-values (padj) for multiple comparisons.
• Raw data is publicly available via ProteomeXchange with identifier PXD067936.
• The dataset is licensed under CC-BY-4.0, allowing for reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (104.6 KB), indicating a limited scope of proteins or conditions.

Provenance

Source

figshare

Collection Method

DIA mass spectrometry was applied to identify and quantify proteins. Peptides and protein groups were identified using Spectronaut and quantified by summing up precursor signal areas under the curve.

Freshness

Last updated 2026-04-30 04:13:33; freshness should be verified.