Friesian Horse Genomic Data on Lethal Haplotypes and Fertility Outcomes

Additional file 2 from a study on recessive lethal variants in Friesian horses. The dataset includes 70K SNP Chip data from 8,263 horses, with tables covering filtered SNPs, haplotype sequences, and mating outcome statistics. It was authored by Marije J. Steensma and last updated on 2026-04-17.

Use Cases

• Identify candidate lethal haplotypes based on homozygous deficiency analysis described in Table S4.
• Analyze the impact of carrier status on insemination success and juvenile mortality using the mating outcome tables (S5, S6).
• Validate PCR primers for candidate variants as detailed in Table S3.
• Examine high-impact genetic variants associated with specific haplotypes listed in Table S7.
• Compare RNA sequence similarity for non-coding RNAs within a large deletion region using nBLAST results from Table S8.

Strengths

• Includes data from 8,263 horses, providing a substantial sample size for genetic analysis.
• Contains multiple specific tables (S1-S9) covering SNP data, primer design, haplotype sequences, and phenotypic outcomes.
• Uses a Bonferroni-adjusted significance threshold (P < 0.05) for identifying haplotypes with homozygous deficiency.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for individual tables is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific Friesian horse population studied.

Provenance

Source

figshare, authored by Marije J. Steensma.

Collection Method

Analysis of 70K SNP Chip data from horses, with subsequent PCR validation and statistical comparison of mating outcomes.

Freshness

Last updated 2026-04-17 03:58:36; freshness should be verified.

Geography

Likely focused on Friesian horse populations, but specific geographic coverage is not stated.