PDX Models: Single-Cell Multi-Omics of Pancreatic Cancer Dissemination

Patient-derived orthotopic xenograft models provide a 2.1 MB dataset detailing the transcriptional and regulatory programs of pancreatic cancer during peritoneal spread. This supplementary file likely contains single-cell multi-omics analyses from patient-derived organoids, offering a molecular view of metastasis. Its cross-platform presence on figshare signals its role as a key resource for cancer biology research.

Use Cases

• Analyzing transcriptional programs in metastatic pancreatic cancer (inferred from domain, verify after download)
• Validating patient-derived xenograft models for peritoneal dissemination (inferred from domain, verify after download)
• Cross-referencing multi-omics data from organoids with in vivo models (inferred from domain, verify after download)

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution
• Focuses on patient-derived orthotopic xenograft models, which are considered high-fidelity preclinical systems

Limitations

• Metadata is minimal; actual content requires verification after download
• Column names and row counts are not specified, limiting pre-download assessment of structure
• The file size of 2.1 MB suggests the dataset may be a summary or supplementary table rather than raw sequencing data

Provenance

Source

Takaaki Furukawa

Collection Method

Likely generated from experimental analyses of patient-derived orthotopic xenograft models and organoids

Freshness

Last updated on 2026-03-19