QN-302 and Olaparib Synergy: DNA Double-Strand Break Immunodetection in MIA PaCa-2 Cells

Additional file 6 from a 2026 study by Garance Psalmon, published on figshare. The dataset contains measurements of synergistic interactions between the G-quadruplex ligand QN-302 and the DNA repair inhibitor Olaparib. It is a small, 18.3 KB XLSX file assessing DNA double-strand breaks via immunodetection in the MIA PaCa-2 pancreatic cancer cell line.

Use Cases

• Quantify drug synergy scores based on immunodetection data mentioned in the description.
• Analyze DNA double-strand break (DSB) induction from combined drug treatments.
• Validate in vitro findings for G-quadruplex-targeting ligands and PARP inhibitors.
• Compare the efficacy of combination therapy in the MIA PaCa-2 cell line model.

Strengths

• Data is shared under a permissive CC-BY-4.0 license.
• File is small (18.3 KB) and in a widely accessible XLSX format.
• Dataset is directly linked to a specific, peer-reviewed research figure (Table S5).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's scope is limited to a single cell line (MIA PaCa-2).

Provenance

Source

figshare

Collection Method

Likely generated from laboratory immunodetection assays (e.g., γ-H2AX staining).

Freshness

Last updated 2026-05-19 04:15:55; freshness should be verified.