GLYATL1: Differential Gene Expression in Luminal Breast Cancer LTED Cells

Supplementary Table 1 provides log2 fold changes and p-values for differentially expressed genes identified via DESeq2 analysis. Raw RNA-sequencing read counts compare MCF7 parental cells with long-term estrogen-deprived (LTED) cells, a model for endocrine resistance. Janina Müller authored this 2.5 MB Excel file, last updated on April 30, 2026.

Use Cases

• Identify candidate genes associated with endocrine resistance based on differential expression analysis.
• Validate RNA-seq findings from the referenced GHGA dataset (ID: GHGAD23940263267179).
• Perform pathway enrichment analysis using the list of genes with significant log2 fold changes.
• Compare gene expression signatures between hormone-sensitive and hormone-resistant breast cancer cell models.

Strengths

• Analysis includes both raw and FDR-adjusted p-values for rigorous statistical interpretation.
• Data is associated with a specific, cited GHGA raw dataset (ID: GHGAD23940263267179) for traceability.
• File is provided in the structured XLSX format, facilitating direct analysis in spreadsheet or statistical software.

Limitations

• Row count and specific column definitions are unknown, requiring inspection after download.
• Description metadata is limited; actual data quality requires manual inspection after download.
• The 2.5 MB file size suggests a relatively small-scale gene list rather than a full transcriptome matrix.

Provenance

Source

figshare

Collection Method

RNA-sequencing data analyzed with DESeq2 v1.28.1.

Freshness

Last updated 2026-04-30 04:13:32; freshness should be verified