HSF1 and TOP2B Interaction Data with AFM Images and Analysis

A dataset supporting research on the heat shock transcription factor HSF1 and its isoform-specific stimulation of topoisomerase IIB. The collection includes raw atomic force microscopy files, processed images, and analysis files, totaling 29.6 GB. It was authored by Thomas Catley and last updated in May 2026.

Use Cases

• Analyzing HSF1's enhancement of TOP2B DNA binding activity based on atomic force microscopy images.
• Comparing the catalytic engagement of TOP2B versus TOP2A isoforms based on the described biochemical assays.
• Investigating strategies to minimize chemotherapy side-effects based on the pharmacological inhibition of HSF1 described in the associated study.

Strengths

• Includes raw data files (.spm), processed images (.png), and analysis files (.csv) for reproducibility.
• Total dataset size is 29.6 GB, indicating a substantial volume of primary research data.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Row count and specific column definitions are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download or from the manuscript.

Provenance

Source

figshare, authored by Thomas Catley.

Collection Method

Data generated via atomic force microscopy and biochemical assays, as described in the associated manuscript.

Freshness

Last updated 2026-05-15 11:07:35