Mouse Tumor Progression Data Under HZE Radiation and Aging

Gene expression data from 30 tumor samples collected from Lewis lung carcinoma experiments in mice. The dataset was created by the National Aeronautics and Space Administration to investigate how age and space radiation modulate tumor progression. It includes samples from young and middle-aged mice, both irradiated and unirradiated, with RNA analyzed using Illumina BeadArray chips.

Use Cases

• Modeling carcinogenesis risk for astronauts based on age and HZE radiation exposure data
• Analyzing the molecular underpinnings of tumor progression inhibition based on global gene expression profiles
• Comparing tumor growth rates and progression between young and middle-aged hosts
• Investigating the role of specific genes (FASN, AKT1, CXCL12/CXCR4) in radiation-modulated tumor dynamics

Strengths

• Includes 30 tumor sample replicates with specified counts per experimental condition (e.g., 10 samples from young unirradiated mice)
• Experimental design controls for age (143 and 551 days old) and radiation exposure (56Fe irradiation at 1GeV/amu)
• RNA quality was standardized with specific O.D. 260/280 and 28s/18s ratio requirements

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data format is listed as BIN, which may require specialized tools for access and analysis

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from mouse model studies involving tumor cell injection and whole-body irradiation, followed by RNA isolation and gene expression profiling.

Time Range

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Freshness

Last updated 2026-03-13 20:14:17.329812; freshness should be verified

Geography

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