AHA CDA Data Deposit: Mouse and Human MASH Model Data for Thrombosis Research

Mouse and human data provide evidence of exacerbated deep vein thrombosis severity and hypercoagulability in metabolic dysfunction-associated steatohepatitis. The dataset includes RNA-seq results from mouse liver samples, plasma coagulation markers from both species, and results from a thrombin generation assay in a human cohort. Nirav Dhanesha deposited this 12.9 MB dataset on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Analyzing pathways related to inflammation and coagulation based on unbiased RNA-seq of mouse liver samples.
• Comparing plasma markers of coagulation between MASH patients and matched controls.
• Evaluating DVT severity using data from the inferior vena cava partial ligation mouse model.
• Investigating drug mechanisms by studying data on macitentan's inhibition of integrin a9/VCAM-1 interactions.

Strengths

• Includes data from both a well-characterized mouse model and a matched human patient cohort.
• Combines histological, transcriptional, and plasma biomarker data for a multi-faceted analysis.
• File size is 12.9 MB, indicating a focused and likely manageable dataset for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain statistical methods.
• The description focuses on study findings; the exact structure and variables of the deposited data files are not detailed.

Provenance

Source

Research by author Nirav Dhanesha, deposited on figshare.

Collection Method

Data generated from mouse dietary models, unbiased RNA-seq, plasma assays, and a human patient cohort.

Freshness

Last updated 2026-05-18 17:41:47; freshness should be verified.