K2P Channel Expression in 20 Cancer Types from Oncomine Microarray Data

A gene expression analysis of 15 two-pore domain potassium (K2P) channels across 20 cancer types. The dataset compares mRNA expression in cancer versus normal tissue, revealing altered expression for 12 of the 15 family members. The analysis was conducted by Sarah Williams of the University of Southampton using the Oncomine database.

Use Cases

• Identify K2P channels with differential expression in specific cancers based on the Oncomine analysis.
• Explore correlations between channel overexpression/underexpression and cancer types like breast, leukemia, lung, brain, and colorectal.
• Investigate the potential role of specific channels (e.g., K2P1.1, K2P3.1, K2P5.1) in cancer cell behaviors like proliferation and migration.
• Prioritize K2P family members for functional validation in cancer models based on their altered expression profiles.

Strengths

• Analysis covers all 15 members of the mammalian K2P channel family.
• Compares expression across 20 distinct cancer types versus normal tissue.
• Specific findings are reported, such as 12 channels showing altered expression and lists of channels overexpressed or underexpressed.

Limitations

• Row count and specific column-level documentation are unknown; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.
• The dataset description is derived from a research summary; the underlying raw data files and their structure are not detailed.

Provenance

Source

Oncomine (www.oncomine.org) cancer microarray database.

Collection Method

Comparative analysis of mRNA expression data from the Oncomine platform.