BRIC-23: Staphylococcus aureus Gene and Protein Expression in Spaceflight

Staphylococcus aureus RNAIII, a quorum sensing regulator, was upregulated ~88-fold in spaceflight cultures compared to ground controls. This dataset contains multi-omics data from NASA's BRIC-23 experiment, analyzing RNA-Seq and proteomics from bacteria grown for 48 hours on the International Space Station. It was last updated on March 13, 2026.

Use Cases

• Modeling quorum sensing system activation based on differential expression of the agr operon.
• Analyzing virulence potential shifts based on upregulated secreted proteases and phenol-soluble modulins.
• Studying metabolic pathway alterations in spaceflight based on changes in amino acid metabolism and TCA cycle activity.

Strengths

• Data originates from a controlled NASA spaceflight experiment (BRIC-23) on the International Space Station.
• Includes multi-omics analysis combining RNA-Seq and cellular proteomics data.
• Description provides specific differential expression magnitudes, such as an ~88-fold upregulation for RNAIII.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• File format is listed as BIN, which may require specialized tools for access.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Data from the BRIC-23 GeneLab experiment, where S. aureus was grown in BRIC-PDFU units on the ISS and in ground controls for 48 hours.

Time Range

Experimental data from a specific 48-hour growth period.

Freshness

Last updated 2026-03-13 19:57:34.462347; freshness should be verified.

Geography

Data generated from samples on the International Space Station (Low Earth Orbit) and synchronous ground controls.