Amyloid-β and δ-COP Co-assembly: Molecular Interaction Data

851.3 KB of protein structure data from figshare details the direct interaction between amyloid-β (Aβ) and coatomer subunit delta (δ-COP). Anastasia Vlachou published this data in March 2026, showing a two-binding site model and specific peptide sequences involved. Simulations provide mechanistic insights into high-affinity interactions, including a β-bridge between δ-COP I422 and Aβ D23.

Use Cases

• Validate protein-protein interaction models based on the described high-affinity binding site.
• Simulate molecular dynamics based on the specific peptide sequences δ-COP DGEYRHDS and Aβ DAEFRHDS.
• Investigate the role of the I422 mutation in δ-COP based on the comparison with T422 highlighted in the description.
• Analyze β-sheet co-assembly structures based on the 'co-assembly-like' interaction mechanism described.

Strengths

• Data includes specific, experimentally suggested peptide sequences for interaction sites.
• File format is PDB, a standard for protein structure data.
• License is CC-BY-NC-4.0, allowing non-commercial reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 851.3 KB size indicates a limited scope, likely containing only specific interaction models.

Provenance

Source

figshare

Collection Method

Generated from experiments and molecular simulations as described.

Freshness

Last updated 2026-03-19 14:36:25