Trimethoprim-Sulfathiazole Cocrystal Data for Synchronized Dual-Drug Release

A 889.6 KB dataset contains characterization data for a drug-drug cocrystal of trimethoprim and sulfathiazole. Wen-Hao Li authored this research, which was last updated on 2026-05-29. The data includes results from SCXRD, PXRD, DSC-TG, IR spectroscopy, hygroscopicity, solubility, dissolution, and in vivo pharmacokinetic evaluations.

Use Cases

• Modeling synchronized drug release profiles based on cocrystal dissolution data.
• Analyzing the impact of cocrystallization on pharmacokinetic parameters like Tmax.
• Comparing the hygroscopicity and solubility of cocrystals versus physical drug mixtures.

Strengths

• Data includes multiple characterization methods: SCXRD, PXRD, DSC-TG, and IR spectroscopy.
• In vivo pharmacokinetic results show a specific Tmax shift from a 110-minute gap to a unified 90 minutes.
• Systematic evaluation covers hygroscopicity, solubility, and dissolution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Experimental characterization of a synthesized cocrystal, as described in the associated study.

Freshness

Last updated 2026-05-29 04:45:07; freshness should be verified.