Synthesis Data for Halogenated Tetramethoxynaphthalene Building Blocks

A 2026 figshare upload by Gaoyang Yuan details a streamlined synthesis method for halogenated 1,4,5,8-tetramethoxynaphthalenes. The dataset includes supporting documentation confirming structures via NMR, FT-IR, and HRMS. It reports overall yields of 33.3%, 26.7%, and 8.1% for the bromo, iodo, and chloro derivatives, respectively.

Use Cases

• Benchmarking synthetic route efficiency based on reported yields of 33.3%, 26.7%, and 8.1%.
• Planning scale-up procedures based on the described simple work-up and readily available reagents.
• Identifying spectral reference data for halogenated naphthalenes based on the NMR, FT-IR, and HRMS confirmation mentioned.

Strengths

• Includes specific yield data: 33.3% for 2-bromo, 26.7% for 2-iodo, and 8.1% for 2-chloro derivatives.
• Method is described as streamlined, with simple work-up and readily available reagents.
• Structures were confirmed by multiple analytical techniques: NMR, FT-IR, and HRMS.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (7.1 MB), likely containing documentation rather than extensive raw data tables.

Provenance

Source

Gaoyang Yuan via figshare

Collection Method

Laboratory synthesis and analytical characterization.

Time Range

2026

Freshness

Last updated 2026-04-16 22:00:03.

Geography

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