RNA-Focused DEL Platform: Ligands for ALS/FTD-Associated RNA

A DNA-encoded library enriched for RNA-binding scaffolds was constructed to discover ligands for the pathogenic r(G4C2)exp RNA repeat. The dataset likely contains results from DEL selections analyzed through large-scale molecular docking and physicochemical analyses. The data was published by Xueyi Yang on figshare in May 2026 under a CC-BY-NC-4.0 license.

Use Cases

• Validate docking predictions against experimental enrichment trends based on the described selection outcomes.
• Perform structure–activity relationship (SAR) analysis on lead compounds and their analogues.
• Identify privileged RNA-binding scaffolds from the described diverse, solid-phase DEL.
• Optimize lead compounds for enhanced binding affinity and bioactivity using rational design principles.

Strengths

• The dataset is associated with a published methodology combining DNA-encoded library technology with computational approaches.
• The dataset file size is 29.1 MB, indicating a contained but potentially detailed set of results.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

figshare

Collection Method

Constructed from a solid-phase DNA-encoded library and analyzed through molecular docking and SAR.

Freshness

Last updated 2026-05-08 06:03:38; freshness should be verified.