Kinome Atlas of Adipose Tissue Depots in Obese and Lean Mice

Kinase activity was characterized across five adipose tissue depots in obese versus lean mice using PamGene kinome technology. The dataset, authored by Terry Hinds and last updated in May 2026, includes analyses of human and mouse preadipocytes compared to their mature adipocytes. It identifies depot-specific combinations of hyperactive and hypoactive kinase pathways involved in adiposity.

Use Cases

• Identify potential drug targets for anti-obesity therapies based on depot-specific kinase activity.
• Compare kinase pathway responsiveness between preadipocytes and mature adipocytes.
• Investigate the functional heterogeneity of different anatomical fat depots in response to weight gain.

Strengths

• Data generated using advanced PamGene kinome technology.
• Compares kinase activity across five distinct adipose tissue depots.
• Includes parallel analysis of human preadipocytes and mouse 3T3-L1 cells.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data files are in DOCX and TXT formats, which may require parsing for structured analysis.

Provenance

Source

figshare

Collection Method

Kinase activity characterized using PamGene kinome technology in mouse adipose depots and cultured cells.

Freshness

Last updated 2026-05-09 02:22:04; freshness should be verified.