Angiopep-2-Decorated Vesicles for Glioblastoma Therapy: In Vitro and In Vivo Data

Engineered bacterial outer membrane vesicles were designed to penetrate the blood-brain barrier for glioblastoma treatment. The dataset, authored by Pir Tariq Shah and last updated in April 2026, includes research documents detailing in vitro BBB model results and in vivo imaging from orthotopic GBM models. Results show accelerated brain accumulation within 2–4 hours and sustained retention for 6 hours post-injection.

Use Cases

• Study blood-brain barrier penetration mechanisms based on the described LRP1 receptor-mediated transcytosis.
• Analyze tumor suppression efficacy based on described DOX-induced apoptosis and immunomodulation.
• Investigate immune response dynamics based on described IFN-γ elevation and immune cell recruitment.
• Evaluate a genetic engineering platform based on the described AIDA-I autotransporter and pAIDA1-ANG plasmid.

Strengths

• Data is associated with a specific, novel genetic engineering approach using an AIDA-I autotransporter.
• Research includes both in vitro BBB model and real-time in vivo imaging validation.
• Results include specific temporal metrics, such as brain accumulation within 2–4 hours and retention for 6 hours.
• Dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (3.3 MB), suggesting it contains documentation rather than large-scale experimental data.

Provenance

Source

figshare

Collection Method

Generated from laboratory research involving genetic engineering of E. coli and testing in orthotopic glioblastoma models.

Freshness

Last updated 2026-04-17 04:40:04; freshness should be verified.