Antifungal resistance and <i>Ocimum gratissimum</i> L. essential oil–clotrimazole interact

Dang Anh Tuan's dataset comprises 423 clinical Candida isolates collected from a Vietnamese tertiary hospital in 2017–2018. It includes species distribution, antifungal susceptibility results for fluconazole, voriconazole, and amphotericin B, and in-vitro assays evaluating Ocimum gratissimum essential oil interactions with clotrimazole. The dataset was last updated on 2026-04-28.

Use Cases

• Analyze Candida species distribution and antifungal resistance patterns based on the described 423 clinical isolates.
• Study the anti-biofilm activity of Ocimum gratissimum essential oil based on the crystal violet assay results for C. albicans.
• Investigate synergistic drug interactions based on the Fractional Inhibitory Concentration Index (FICI) results for OGEO and clotrimazole.
• Benchmark fluconazole resistance rates in a specific hospital cohort based on the reported 13.7% overall resistance.

Strengths

• Contains data from 423 clinical Candida isolates, providing a substantial sample size for analysis.
• Reports specific quantitative results, including a 13.7% overall fluconazole resistance rate and OGEO biofilm inhibition of 71.2% at 1% concentration.
• Includes detailed methodological descriptions for species identification, susceptibility testing, and interaction assays.

Limitations

• Species-level identification was available for only 212 of the 423 isolates, limiting precise species-specific resistance analysis.
• Row count and column-level documentation are unknown, which may limit suitability assessment and require manual inspection after download.
• Data reflects a specific temporal (2017-2018) and geographic (Vietnamese hospital) context, which may limit generalizability.

Provenance

Source

figshare, author Dang Anh Tuan

Collection Method

Retrospective analysis of clinical isolates using phenotypic methods, VITEK 2, CLSI M27-A3 susceptibility testing, GC–MS, crystal violet, and checkerboard assays.

Time Range

2017–2018

Freshness

Last updated 2026-04-28 08:54:29; freshness should be verified.

Geography

Vietnam (tertiary hospital)