Antitumor Activity of Silver Complexes in Colorectal Cancer Cells

Two synthesized bis(phosphine)silver(I) complexes demonstrated potent activity against colorectal cancer cells, surpassing the efficacy of the precursor compound and cisplatin. The 505.4 MB dataset includes mechanistic findings on reactive oxygen species production and apoptosis induction. Author Sin-Yeang Teow published the data on figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-05-18.

Use Cases

• Evaluating the anticancer efficacy of novel silver complexes based on proliferation inhibition data for HCT116 and HT-29 cell lines.
• Studying mechanisms of cell death in cancer research based on described reactive oxygen species (ROS) and superoxide production.
• Comparing drug potency in 3D spheroid models based on the described disintegration activity of Ag1 and Ag2 complexes.
• Investigating structure-activity relationships in drug discovery based on the thiocarbamide moiety in the synthesized complexes.

Strengths

• Dataset size is 505.4 MB, indicating substantial supporting material.
• Includes comparative efficacy data against established drugs like cisplatin and oxaliplatin.
• Mechanistic insights on oxidative stress and apoptosis are described in the summary.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The data files are in TIFF and DOCX formats, which may require specific tools for analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental research evaluating synthesized silver complexes.

Freshness

Last updated 2026-05-18 12:20:30; freshness should be verified.