Applications of visual evoked potentials and Fourier-domain optical coherence tomography i

A cross-sectional observational study quantified pattern-shift visual evoked potentials (VEP) and retinal layer thickness/volume using optical coherence tomography (OCT) in 43 Parkinson's disease patients and 38 age-matched controls. The study was conducted by Lucas Barasnevicius Quagliato and published as an Open Access paper. The main outcome measures were VEP latencies and the thicknesses of retinal layers, including the retinal nerve fibre layer.

Use Cases

• Train models to correlate retinal layer thickness with neurodegenerative disease progression based on OCT measurements.
• Analyze the relationship between visual evoked potential latencies and clinical disease stages (Hoehn-Yahr) mentioned in the study.
• Investigate age-related changes in retinal anatomy using the noted negative correlation between retinal thickness and age.
• Compare anatomical and functional biomarkers (OCT vs. VEP) for evaluating visual pathways in Parkinson's disease.

Strengths

• Includes data from 81 total participants (43 PD patients and 38 controls), providing a basis for comparative analysis.
• Uses high-resolution Fourier-domain optical coherence tomography (OCT) for precise quantification of retinal layer thickness and volume.
• Reports specific numerical results, such as a mean RNFL thickness of 102.7 μm in PD patients vs. 104.2 μm in controls.
• Patient cohort is characterized by specific disease stages (34.8% in Hoehn-Yahr stage 1/1.5, 55.8% in stage 2).

Limitations

• Row count and specific column-level documentation are unknown, which limits suitability assessment for direct ML application.
• The dataset is derived from a single study; its generalizability to broader Parkinson's disease populations is unverified.
• Last update date is unknown; freshness unverified.

Provenance

Source

Lucas Barasnevicius Quagliato (via paperswithcode)

Collection Method

Cross-sectional observational study with detailed neurological and ophthalmologic evaluation, VEP, and OCT assessments.